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American Conference on Pharmacometrics (ACoP)

The 2013 American Conference on Pharmacometrics will be held in sunny Fort Lauderdale Florida, May 12th – 15th. This program promises to meet the exemplary educational and networking standards that are a hallmark of our new and growing organization.

The Program Chairs, Drs. Brian Corrigan and Parviz Ghahramani, have arranged for an extraordinary group of lecturers from around the world, brought together to highlight the latest research and techniques in Pharmacometrics. Program highlights include lectures from great speakers on physiological based modeling, systems pharmacology, adaptive trial design, as well as therapeutically aligned presentations.

For the first time at ACoP, we have introduced concurrent sessions, so that you will be able to tailor your day to your specific needs and interests. Also new this year is a free "Tutorials" session, where you will have the opportunity to learn new skills and approaches to pharmacometric data analysis. In addition, we will have a state-of-the-art lecture from the National Oceanic and Atmospheric Administration (NOAA), highlighting techniques for handling models with "big data" to forecast storms such as Superstorm Sandy.

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Workshop:  Using MATLAB® and SimBiology® for Mechanistic Systems Pharmacology Workflows
Presenter: Asawari Samant, Scott Wakefield
Date: Thursday, May 16, 2013
Time: 9:00a.m. –  5:00p.m.

This introductory workshop will give participants a hands-on experience with implementing systems pharmacology workflows using MATLAB® and SimBiology®. MATLAB is an interactive environment for data analysis and visualization that is extensively used by scientists and engineers. SimBiology® is MATLAB-based tool that provides a graphical environment for modeling and simulating dynamic (ODE-based) systems, focusing on mechanistic systems biology and pharmacokinetic /pharmacodynamic (PK/PD) applications.

The first half of the workshop will adopt a model-driven approach that focuses on building and simulating mechanistic and semi-mechanistic models. Hands-on examples will walk participants through the process of building mechanistic models by dragging and connecting components in a block diagram environment. Participants will also learn about various simulation-related features: simulation settings, using variants to simulate alternate animal species or conditions and simulating dosing schedules. The Simulation Viewer – an interactive tool to explore model dynamics – will also be covered.

In the second half, participants will learn how to apply SimBiology to implement traditional, data-driven PK/PD workflows. This section will focus on data import and visualization, non-compartmental analysis and estimation. The workshop will conclude with examples of integrating SimBiology models with other parts of the MATLAB tool chain, such as parallel computing, global optimization and deployment; some examples of integration with MATLAB are listed in the detailed schedule below.

Prior experience with MATLAB or SimBiology is NOT required. Attendees are expected to have a basic understanding of compartmental PK/PD and mechanistic modeling concepts.

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Locations & Dates

Fort Lauderdale, FL
12 Mai 2013